While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects. Tentative evidence suggests that sildenafil may help men who experience antidepressant-induced erectile dysfunction. Antidepressant-associated sexual dysfunction Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus.
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse). Pfizer Viagra tablet in the trademark blue diamond shape Sexual dysfunction Most of the Active Pharmaceutical Ingredient (API) in Sildenafil, Sildenafil citrate, is produced in Pfizer's Ringaskiddy complex, County Cork, which is Pfizer's largest production facility outside of the United States. In the United Kingdom, it is available over the counter. In 2020, it was the 183rd most commonly prescribed medication in the United States, with more than 2 million prescriptions. It was approved for medical use in the United States and in the European Union in 1998. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain. It also results in dilation of the blood vessels in the lungs. Sildenafil acts by blocking phosphodiesterase 5 (PDE 5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. Sildenafil should not be taken within four hours of taking an alpha blocker. Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. Rare but serious side effects include a prolonged erection (priapism) that can lead to damage to the penis, vision problems, and hearing loss. Caution is advised in those with cardiovascular disease. Ĭommon side effects include headaches, heartburn, and flushed skin. Onset is typically within twenty minutes and lasts for about two hours. It is taken by mouth or by injection into a vein. It is unclear if it is effective for treating sexual dysfunction in women. Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.
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